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THYMOSIN BETA 4 / TB500
Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin beta-4, is an actin, a cell building protein.
One of the main mechanisms of action of Thymosin Beta-4 is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which leads to its role in tissue repair. Tβ 4 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissues. After an injury, Tβ 4 is released by platelets and numerous other types of cells to protect the most damaged cells and tissues and to reduce inflammation and microbial growth.
Benefits of Thymosin Beta-4
Thymosin beta-4 has a range of benefits throughout the body. Some key features to note include:
Calms muscle spasm
Improved muscle tone
Increased exchange of substances between cells
Encourages tissue repair
Stretches connective tissue
Helps maintain flexibility
Reduced inflammation of tissue in joints
Encourages the growth of new blood cells in tissue
Increased endurance and strength
Prevents the formation of adhesions and fibrous bands in muscles, tendons, and ligaments
Reduces the infarct size and improves heart contractile performance
Therapeutic effect on corneal injury and dry eye syndrome
Antifibrotic effect on the liver
Accelerates hair growth
How Thymosin Beta-4 Works
Recent studies have revealed that the first gene to be upregulated after an injury is a Tβ4 gene. As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a number of other conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive.
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following a heart attack due to its cardio and neuroprotective effects.
TB500
TB-500 is a synthetic fraction of the 43 amino acid protein thymosin beta-4. The main purpose of this peptide is to promote healing. The healing effects of TB-500 have been observed in tendons, ligaments, muscles, skin, heart, and eyes. It aids in the quick healing of wounds by promoting new blood vessel and muscle fiber growth. It upregulates cell building proteins like actin. It is fast acting and goes to the site of the injury once injected and starts to work. Benefits include:
Increases cells in healing
Promotes angiogenesis (blood vessel formation)
Decreases inflammation
Improves cell migration to the cite of the injury
Soft tissue repair - tendon, ligament, muscle sports, and athletic injuries
Reduces scar tissue and adhesions, helps maintain flexibility
Significant repair and regenerative properties
Enlarged muscle growth, muscle tone, and muscular stamina
Side Effects
Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable peptide.